Like clockwork, the YSN-ASM Colloquium is here again. This annual programme is organised by the Young Scientists Network-Academy of Sciences Malaysia. This year, the Colloquium was held virtually from 4 to 5 December 2020 in view of the current pandemic situation, keeping everyone safe and sound in the comfort of their homes or office. Boasting the highest attendance to date, the 2020 YSN-ASM Colloquium continues its role as an avenue for the YSN-ASM members and affiliates to gather, get acquainted, build network, and formulate programmes to advance the nation’s science, technology, and innovation.